People With Manic depression.
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Could a weight -loss pill cause serotonin syndrome or further depression?
A few years ago I took Adipex and it worked wonders-I lots 60 pounds.I kept it off for over 3 tears,until I had my daughter.I've tried everything,and nothing works.Although I want to go back to using Adipex or Meridia,I'm afraid b/c it's made me feel "funny in the past.I suffer from manic-depression,and since these meds work altering serotonin levels,I'm afraid they might harm me.Is it safe for people with depression to take the pills?What is the actual effect these have on the brain and mood?
The short answer is yes. Any drug (in theory) that increases your serotonin could cause serotonin syndrome. But most of the time serotonin syndrome is caused by taking multiple serotonergic drugs at a high dose. So taking Prozac, Tramadol, Adderall, Meridia, and Singular might be unwise. And both Meridia and Adipex do increase serotonin. However, Adipex causes very little release of serotonin (possibly even none at a low dose). Adipex works primarily with norepinephrine. Meridia on the other hand is chemically an antidepressant (but it has no clinical evidence for reducing depression). Meridia does reduce the reuptake of serotonin, norepinephrine and dopamine. The chemical action of reducing the reuptake of a neurotransmitter is the same for an antidepressant. Most stimulants including Adipex (but not Meridia) force the release of these neurotransmitters (with Amphetamines and Cocaine being the most powerful and also causing the most weight loss).
Since you are Bipolar stimulants and antidepressants are typically counter indicated. But you did take Adipex and (I assume) it did not cause a manic episode. Also, antidepressants are often given to people with Bipolar but always in conjunction with a mood stabilizer (Lithium, Depakote, Lamictal, Tegretol, Trileptal, Abilify, Risperdal, Zyprexa, Seroquel). But drugs like Risperdal and Zyprexa can cause weight gain. Even drugs like Adderall or Ritalin are often given to people with Bipolar but, like I said, always with other drugs.
So I would NOT take Meridia. You have used Adipex and it worked well so I would not do something that has more risks and does not work as well (for most people).
You could be at risk but if you now take (or decide to take) a Mood Stabilizer (but that is just a thought if you want to be extra careful), make sure friends and family close to you know what is going on (so they can monitor for mania), and see your doctor on a regular basis then I would think it would be perfectly fine to take Adipex. And if you made it through your pregnancy without having a manic episode that is a good sign (most women with Bipolar will become manic at some point during pregnancy).
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What does manic depression look like in a person - which they are in a mania state?
Any experiences with seeing someone going through this state? How do/did you ground them back in reality? Do you have to always seek medical advice or is there a point where it is just manageable? There is this guy I know who is clearly in his manic phrase but I am just wondering how far people with this condition are 'allowed' to go into it until they are deemed unsafe to themselves? Is it ok to be a little bit manic but not fully into it or is immediate action taken when the first signs of a manic phrase are begining?
Thanks
It's not easy to judge these things. Do you know your friend's pattern? Some people just go into a manageable level of mania and don't go so high that they become a danger to themselves. Others go over the top and if that is this guy's pattern, it might be necessary to seek help. Usual things to watch for are spending as if the bank was full of your money.... that's commonly the one that has most lasting repercussions. The hyperactivity is only a problem if the people around can't cope and can't find a way to make things OK for everyone. It's truly problematic when people get ideas that the rest of us see as really off the wall and damage other people's lives - eg setting fire to things.
You might find it worth reading a book called "An Unquiet Mind" by Kay Redfield Jamison. She's a psychiatrist who herself suffers from manic-depression and got through her training because of good friends who kept her safe during the manic phases and ensured that the authorities didn't get to know..... She is now a real expert on the condition, obviously. Her book is autobiographical, and gives lots of good info and understanding.
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